Dr. Battinelli at ASH 2022
Dr. Battinelli presented at an ASH 2022 scientific workshop entitled the Interplay Between Coagulation and Malignancy. Her presentation focused on the potential contributions of platelets to cancer immune escape.
Dr. Battinelli presented at an ASH 2022 scientific workshop entitled the Interplay Between Coagulation and Malignancy. Her presentation focused on the potential contributions of platelets to cancer immune escape.
Here, we report that co-culturing platelets with cancer cells increased tumor cell Programmed death ligand 1 (PD-L1), which was reduced by antiplatelet agents. We determined that platelet epidermal growth factor (EGF) increased tumor cell PD-L1, likely through an EGFR-dependent mechanism.…
The Battinelli lab recently published that breast cancer–induced alterations in megakaryocytes lead to qualitative changes to platelets that promote tumor metastasis. In this study, we used a spontaneous murine model of breast cancer to show that tumor burden reduced megakaryocyte…
Michael Malloy will be presenting a poster on his and Qiuchen Guo’s work investigating platelet-induced upregulation of PDL-1 on tumor cells at the 63rd ASH Annual Meeting.
Harvey Roweth and Elisabeth Battinelli recently published a comprehensive review article in the journal Blood discussing the complex mechanisms by which tumor cells “educate” circulating platelets. These tumor-educated platelets have received significant attention as a potential liquid biopsy for solid…